Lipid management and Familial Hypercholesterolaemia (FH)

The NHS Long Term Plan states that the biggest area where we can save lives is in reducing the incidence of Cardiovascular Disease (CVD).

CVD causes a quarter of all deaths in the UK and is the largest cause of premature mortality in deprived areas.

Hypercholesterolaemia (high blood cholesterol) is a significant risk factor for CVD. 

Evidence suggests that improving the detection and treatment of those with hypercholesterolaemia will have significant benefits.

UCLPartners is working with acute trusts, and primary and community care teams on a wide programme of work including:

Health Innovation Network FH and Lipid Management programme

The Health Innovation Network programme aims to:

• improve the management of cholesterol,
• increase the detection of those with Familial Hypercholesterolaemia
• optimise the use of all medicines for patients on the cholesterol management pathway.

There are 3 focus areas:

• Familial Hypercholesterolaemia (FH) detection and lipid management optimisation to reduce death and disability due to premature CVD. This includes expanded access to genetic testing for FH via screening of electronic records.
• Working in partnership with the Accelerated Access Collaborative (AAC) Rapid Uptake Products (RUP) lipid management programme to accelerate patient access to appropriate medicines to enable lipid treatment using the NICE-recommended clinical pathway, with a focus on secondary prevention and including novel therapies.
• In partnership with HEARTUK, The Health Innovation Network are delivering the Tackling Cholesterol Together education programme and the Cholesterol Now campaign. The Education Programme aims to provide clinicians and managers with the opportunity to learn about different elements of the lipids pathway, from internationally regarded experts in the field and supports the broader objectives of our lipids national programme.

Familial Hypercholesrolaemia (FH) Pilot

UCLPartners is collaborating with the North Thames Genomic Medicine Service Alliance to implement a pilot programme with Primary Care Networks to identify patients with FH and provide them with appropriate care.

Inclisiran delivery

UCLPartners are taking a whole pathway approach while working with stakeholders. This ensures that the new treatment fits seamlessly within the updated lipids care pathway and provides more treatment options to high-risk patients who remain at risk despite maximum tolerated statin therapy via new novel technologies and existing unused treatment options.

Healthcare professionals can read summary information on the supply and funding of Inclisiran from NHS England.

For support to embed Inclisiran in local pathways please contact primarycare@uclpartners.com

Past webinars

Managing CVD risk factors

This webinar covers:

• Practical session for clinicians as to why AF, Blood Pressure and cholesterol all needs to be managed
• Show the case for change and how, in practice, a patient could be managed
• Promote the PC framework approach

Resources:

• Managing CVD risk factors webinar recording
• Managing CVD risk factors webinar presentation

Cholesterol – A national priority & understanding the national pathway

This webinar covers:

• National ambitions for cholesterol
• Drivers and incentives for delivery
• The national AAC / NHSE pathway and current gaps in delivery

Resources:

• Webinar recording
• Webinar presentation

Optimising lipid management

This webinar covers:

• Demonstrate the Proactive Care framework for lipids
• Lifestyle and behaviour change
• Statins and intensification of therapy beyond statins – ezetimibe, inclisiran, PCSK9i mAB and bempedoic acid
• Primary and secondary prevention case studies

Resources:

• Webinar presentation

Lipid management: case study on implementation of the proactive care frameworks in BHR

This webinar covers:

• Show case the role of pharmacy in managing high risk patients
• Show case the approach taken in the administration of inclisiran in north east London through Redbridge PTF
• Highlight suggested training and competencies
• Allow time for breakouts/ discussion as to what support local systems need to make this happen

Resources:

• Webinar recording
• Webinar presentation

FH – overview

This webinar covers:

• What is FH
• How can it be managed
• Demonstrate pathway for FH
• Case study from North east London

Resources:

• Webinar recording
• Webinar presentation